Webster's Revised Unabridged Dictionary · 1913

Manuscript

Manuscript , adjective

[Latin manu scriptus. See Manual, and Scribe.]

Written with or by the hand; not printed; as, a manuscript volume.

Manuscript , noun

[Late Latin manuscriptum, lit., something written with the hand. See Manuscript, a.]

1.
An original literary or musical composition written by the author, formerly with the hand, now usually by typewriter or word processor. It is contrasted with a printed copy.
2.
Writing, as opposed to print; as, the book exists only in manuscript. — Craik

The word is often abbreviated to MS., plural MSS.