Webster's Revised Unabridged Dictionary · 1913

Vicissitude

Vicissitude , noun

[Latin vicissitudo, from vicis change, turn: compare French vicissitude. See Vicarious.]

1.
Regular change or succession from one thing to another; alternation; mutual succession; interchange.
God made two great lights... To illuminate the earth and rule the day In their vicissitude, and rule the night. — Milton
2.
Irregular change; revolution; mutation.
3.
Changing conditions of fortune in one's life; life's ups and downs.
This man had, after many vicissitudes of fortune, sunk at last into abject and hopeless poverty. — Macaulay