Webster's Revised Unabridged Dictionary · 1913

Inefficacy

Inefficacy , noun

[Latin inefficacia. See In- not, and Efficacy.]

Lack of power to produce the desired or proper effect; inefficiency; ineffectualness; futility; uselessness; fruitlessness; as, the inefficacy of medicines or means.
The seeming inefficacy of censures. — Bp. Hall
The inefficacy was soon proved, like that of many similar medicines. — James Gregory