Webster's Revised Unabridged Dictionary · 1913

Inefficacious

Inefficacious , adjective

[Prefix in- not + efficacious: compare French inefficace, Latin inefficax.]

Not efficacious; not having power to produce the effect desired; inadequate; incompetent; inefficient; impotent. — Boyle
The authority of Parliament must become inefficacious... to restrain the growth of disorders. — Burke

Ineffectual, says Johnson, rather denotes an actual failure, and inefficacious an habitual impotence to any effect. But the distinction is not always observed, nor can it be; for we can not always know whether means are inefficacious till experiment has proved them ineffectual. Inefficacious is therefore sometimes synonymous with ineffectual.