Exacerbate
Exacerbate (egz*as"ẽr*bāt; 277) , transitive verb
[Latin exacerbatus, past participle of exacerbare; ex out (intens.) + acerbare. See Acerbate.]
To render more violent or bitter; to irritate; to exasperate; to imbitter, as passions or disease. — Brougham